Targeting the unwindosome by mebendazole is a vulnerability of chemoresistant hepatoblastoma

HIGHLIGHTS

• who: Qian Li and colleagues from the Department of Pediatric Surgery, Drvon Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany have published the research: Targeting the Unwindosome by Mebendazole Is a Vulnerability of Chemoresistant Hepatoblastoma, in the Journal: Cancers 2022, 4196 of 15/02/2019
• what: The authors focused on the three PDX cell lines HB-214, HB-282, and HB-303, which showed the highest sensitivity to mebendazole, with clinically achievable IC50 values of 1.63 µM, 4.53 µM, and 1.59 µM, respectively. The authors selected this PDX line because . . .
  

   

  

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