HIGHLIGHTS
- who: Cheng-Long Hu from the (UNIVERSITY) have published the research work: Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia, in the Journal: (JOURNAL) of 27/Oct/2022
- what: The authors showed that deletion of UHRF1 significantly prolongs the survival time of the mice with AML by targeting the self-renewal of leukemia initiating cells through SAP30-mediated MXD4 activation.
- how: The results showed that the UHRF1 mRNA and protein levels were higher in AML patient samples compared with the healthy controls (Fig 1au2012c Supplementary information Fig S1a . . .
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