Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss

HIGHLIGHTS

• What: The concomitance of therapeutic and deleterious impacts of GCs drives the research focus in two directions: one is to unravel the mechanisms underlying GCs therapeutic anti-inflammatory and immunosuppressive actions, and the second is to search for the knowledge behind the side effects of prolonged exposure to pharmacological concentrations of GCs, including GIO. From a different perspective, the authors report herein that therapeutic effects and side effects of GCs are mediated by separate mechanisms through binding to distinct receptors with different affinities. The authors report that upon binding with high-dose dexamethasone, non-microtubule-associated cytoplasmic . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.