Tcf-1 limits the formation of tc17 cells via repression of the maf-rorγt axis

HIGHLIGHTS

• who: Lisa A. Mielke and collaborators from the Rockefeller University Press JExp. Med. , Vol. , No. , have published the Article: TCF-1 limits the formation of Tc17 cells via repression of the MAF-RORγt axis, in the Journal: (JOURNAL) of 01/07/2022
• what: The authors demonstrate that the transcription factor TCF-1 (Tcf7) regulates CD8+ T_cell fate decisions in double-positive (DP) thymocytes through the sequential suppression of MAF and RORγt, in parallel with TCF-1-driven modulation of chromatin state. The authors demonstrate that the loss of TCF-1 results in the . . .
  

   

  

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