Telomere shortening causes distinct cell division regimes during replicative senescence in saccharomyces cerevisiae

HIGHLIGHTS

• who: Hugo Martin from the JL Lions Laboratory, France have published the research work: Telomere shortening causes distinct cell division regimes during replicative senescence in Saccharomyces cerevisiae, in the Journal: (JOURNAL)
• what: The authors provide a mathematical description of sequences of non-terminal arrests to understand how they appear. Using numerical simulations the authors show that the occurrence of non-terminal arrests is a generation-dependent process that can be explained by the shortest telomere reaching a probabilistic threshold length. Using this model, the authors and others showed that telomerase-negative cells often experience consecutive . . .
  

   

  

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