HIGHLIGHTS
- who: Natalia Maciejewska from the (UNIVERSITY) have published the research work: Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres, in the Journal: (JOURNAL) of 31/05/2022
- what: The authors propose the development of a new therapeutic approach that efficiently targets hTERT. The authors analyzed the antitumor activity of these compounds in cancer cell lines characterized by different telomere elongation mechanisms. Evaluation of TXT as a telomerase inhibitor using molecular docking analysis On the basis of FRET data showing that TXT compounds are devoid of G4 stabilizing properties, the authors focused . . .
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