Temporal dynamics of ras mutations in circulating tumor dna in metastatic colorectal cancer: clinical significance of mutation loss during treatment

HIGHLIGHTS

• What: The authors aimed to investigate the temporal dynamics of the and its clinical significance. In this study, aRAS-ML was defined as the absence of RAS mutations after treatment initiation in patients who were diagnosed with RAS-MT (KRAS exons 2, 3, 4 or NRAS) upon pre-treatment tissue examination; mutation loss was determined based on the findings of the transient ­OncoBEAM™ RAS CRC assay. This study analyzed the temporal dynamics of the ctDNA RAS and suggests that it may serve as a marker for treatment response. This study has some other limitations.
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