Terminal deoxynucleotidyl transferase indiscriminately incorporates ribonucleotides and deoxyribonucleotides*

HIGHLIGHTS

• who: Jean-Baptiste Boule̕ from the (UNIVERSITY) have published the paper: Terminal Deoxynucleotidyl Transferase Indiscriminately Incorporates Ribonucleotides and Deoxyribonucleotides*, in the Journal: (JOURNAL) of June/13,/2001
• what: The authors report that the short murine TdT, which is the isoform conserved across the vertebrate phylum , has only minor preference for the incorporation of deoxyribo- over ribonucleotides on DNA strands in_vitro and that under conditions that reproduce the in_vivo ribo/deoxyribonucleotide pool imbalance , incorporation of ribonucleotides by TdT leads to premature termination of chain elongation. The authors demonstrate that TdT extends a ribonucleotide-terminated initiator with . . .
  

   

  

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