HIGHLIGHTS
- who: Gamze Bildik from the This study was approved by the Institutional Review Board of Koc University (IRB#, .IRB2.069). Patients have published the research: Terminal differentiation of human granulosa cells as luteinization is reversed by activin-A through silencing of Jnk pathway, in the Journal: (JOURNAL)
- what: The authors report that activin-A after binding to its cognate receptors induces a functional luteolytic state and reverses luteinization phenotype by downregulating the expression of the steroidogenic enzymes LH receptor and VEGF and reducing estradiol (E2) progesterone (P4) production and upregulating FSH receptor and cyclin D1 . . .
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