Tgfβ-induced changes in membrane curvature influence ras oncoprotein membrane localization

HIGHLIGHTS

• who: Alexandros Damalas from the DepartmentUniversity of have published the research work: TGFu03b2-induced changes in membrane curvature influence Ras oncoprotein membrane localization, in the Journal: Scientific Reports Scientific Reports
• what: For the experiments the authors thus used hyposmotic level shown to be required to reduce caveolae by ~ 30%30. The authors showed that TGFu03b2-1 treatment of breast cancer cells MCF7 is followed by elevated PM localization of activated H-ras and K-ras. The novel TGFu03b2-EMT feedback loop the authors propose here, which leads to H-Ras membrane localization and activation, is . . .
  

   

  

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