Tgfβ reprograms tnf stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis

HIGHLIGHTS

• who: Yuhan Xia from the Tissue Degeneration Program and David ZRosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York, USASouth University have published the research work: TGFu03b2 reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors generated TGFu03b2 receptor 2 conditional knockouts (KO) mice (Tgfbr2f/f;LysMCre) and show that deficiency of TGFu03b2 signaling pathway in macrophages/osteoclast precursors does not affect RANKL-induced osteoclastogenesis in_vitro and in_vivo, or bone mass, providing clear evidence that TGFu03b2 signaling is . . .
  

   

  

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