Tgf 3, dibutyryl camp and a notch inhibitor modulate phenotype late in stem cell-derived dopaminergic neuron maturation

HIGHLIGHTS

• who: TYPE and colleagues from the Hanyang University, South Korea Taiwan have published the paper: TGF 3, dibutyryl cAMP and a notch inhibitor modulate phenotype late in stem cell-derived dopaminergic neuron maturation, in the Journal: (JOURNAL)
• what: The authors maintain mature mDA neurons in the presence of GDNF, BDNF, dbcAMP, DAPT, and TGFu03b23 and assess the impact that the removal of dbcAMP, DAPT or TGFu03b23 has upon mDA neuron culture development.

SUMMARY

The authors speculate that additive-induced promotion of a dopaminergic phenotype may i) mask inefficient patterning and therefore . . .

 



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