Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle

HIGHLIGHTS

• who: Devine Jackson from the at Nationwide Childrenu2019s Hospital, Columbus, OH, USA have published the Article: Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle, in the Journal: (JOURNAL)
• what: Collectively, the studies show that combined exposure to TNFu03b1 and IFNu03b3 impairs corticosteroid sensitivity in ASM and may contribute to persistent symptoms and exacerbations in severe pediatric asthma. The analysis showed motif enrichment in TIEG1, ETF, MAZ, and KLF15 (Fig 6G). The analysis provides valuable insight into the individual and combined effects of TNFu03b1 and IFNu03b3 of gene_expression . . .
  

   

  

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