HIGHLIGHTS
- who: Ralda Nehme from the Broad Institute Harvard University, Boston, MA, USA have published the research: The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors show that over the course of excitatory neuronal differentiation, the 22q11.2del acts in trans to significantly alter the expression of many genes with established genetic associations with neurodevelopmental disorders in progenitors, and schizophrenia in differentiated neurons. Individual genes within 22q11.2 have been at the center of several studies aiming to identify causal genes underlying the syndrome . . .
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