HIGHLIGHTS
- who: Abramo J. Manfredonia and Daniel A. Kraut from the (UNIVERSITY) have published the article: The 26S Proteasome Switches between ATP-Dependentand -Independent Mechanisms in Response to Substrate Ubiquitination, in the Journal: Biomolecules 2022, 750 of 26/05/2022
- what: The authors show that the proteasome degrades UbID substrates using an ATP-independent mechanism, leading to a lower ability to unfold substrates.
- how: Similar was likely loosely folded not natively unfolded.the Thetime addition of NADPH stabilized the results were obtained for yODC-containing substrates (Supplementary Figurewith S11).
SUMMARY
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