The acidocalcisome inositol-1,4,5-trisphosphate receptor of trypanosoma brucei is stimulated by luminal polyphosphate hydrolysis products

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  • who: Evgeniy Potapenko from the (UNIVERSITY) have published the Article: The acidocalcisome inositol-1,4,5-trisphosphate receptor of Trypanosoma brucei is stimulated by luminal polyphosphate hydrolysis products, in the Journal: (JOURNAL) of May/27,/2019
  • what: The authors show that IP3-mediated Ca2ⴙ release depends on Ca2ⴙ but not on ATP concentration and is inhibited by heparin, caffeine, and 2-aminomethoxydiphenyl borate (2-APB). The authors report the expression and electrophysiological properties of the T. brucei IP3R expressed in DT40 cells devoid of the three vertebrate IP3Rs (DT40 -3KO). By analysis of the TbIP3R . . .

     

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