The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop*

HIGHLIGHTS

  • who: Bo Zhou from the (UNIVERSITY) have published the paper: The Activity of the Extracellular Signal-regulated Kinase 2 Is Regulated by Differential Phosphorylation in the Activation Loop*, in the Journal: (JOURNAL) of January/14,/2002
  • how: The authors showed previously by phosphoamino_acid analysis that exhaustive dephosphorylation of ERK2/pTpY by HePTP or PP2A produced monophosphorylated ERK2/pT or ERK2/pY respectively . Because there were no unphosphorylated ERK2 and other impurity proteins in the ERK2/pTpY sample as judged from SDS-PAGE (Fig 2) Western blot (Fig 3) and mass spectrometric analyses (Fig 5 see . . .

     

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