The af-2 cofactor binding region is key for the selective sumoylation of estrogen receptor alpha by antiestrogens

HIGHLIGHTS

• who: Amandine Vallet from the (UNIVERSITY) have published the article: The AF-2 cofactor binding region is key for the selective SUMOylation of estrogen receptor alpha by antiestrogens, in the Journal: (JOURNAL) of October/17,/2022
• what: The authors show that several AEs induce SUMOylation of ERu03b1, but not ERu03b2, at different levels. The authors report that the SERD fulvestrant has a different impact on SUMOylation of ERu03b1 and ERu03b2, as assessed in transfected HEK293 cells by Western analysis in the absence or presence of the deSUMOylase SENP1 and by BRET assays, which enable evaluation . . .
  

   

  

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