The alzheimer susceptibility gene bin1 induces isoform-dependent neurotoxicity through early endosome defects

HIGHLIGHTS

• who: Erwan Lambert from the Lentiviral constructs were produced by the Vect'UB platform within the TBM Core unit at University of Bordeaux, Bordeaux, France (CNRS UMS, INSERM US, )All three lentiviral constructs harbored reporter tags for the expression of tdTomato protein. The lentiviral vectors used were the empty vector, (ID #, ), Bin Iso, (ID #, ), and, Bin Iso, (ID #, ). Lentiviral infections were done in, week old differentiation cultures obtained from hiNPCs. Viral transductions were performed at a multiplicity of infection (MOI) of, . In brief, appropriate volumes of each construct were mixed in complete BrainPhys medium and , ul of . . .
  

   

  

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