The ameliorative effect of empagliflozin in vigabatrin-induced cerebellar/neurobehavioral deficits: targeting mtor/ampk/sirt-1 signaling pathways

HIGHLIGHTS

  • who: Rabab M. Amer and collaborators from the Anatomy and Embryology Department, Faculty of Medicine, Tanta University, Tanta, Egypt have published the Article: The Ameliorative Effect of Empagliflozin in Vigabatrin-Induced Cerebellar/Neurobehavioral Deficits: Targeting mTOR/AMPK/SIRT-1 Signaling Pathways, in the Journal: Molecules 2022, 3659 of 12/04/2022
  • what: The study herein was designed to investigate the possible ameliorative effect of empagliflozin, the SGLT2 inhibitors, in VGB-induced cerebellar toxicity. Cotreatment with empagliflozin significantly alleviated this effect by increasing the number of squares crossed by the rats in the open field activity . . .

     

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