The amino-terminal region of hepatitis e virus orf1 containing a methyltransferase (met) and a papain-like cysteine protease (pcp) domain counteracts type i interferon response

HIGHLIGHTS

• who: Eugénie Bagdassarian et al. from the INRA, Virologie, Maisons-Alfort, France have published the article: The Amino-Terminal Region of Hepatitis E Virus ORF1 Containing a Methyltransferase (Met) and a Papain-Like Cysteine Protease (PCP) Domain Counteracts Type I Interferon Response, in the Journal: Viruses 2018, 10, 726 of /2018/
• what: This study provides evidence that the predicted MetYPCP of HEV antagonises STAT1 activation to modulate the IFN response.
• how: This result was in agreement with previous findings showing that PCP from HEV-1 ORF1 was an inhibitor of the RLR . . .
  

   

  

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