The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate app stability and metabolism*

HIGHLIGHTS

  • who: Loredana Spoerri from the jugated to horseradish peroxidase at, :10, (both from GE Healthcare)The following antibodies were used for immunocytochemistry: , at, :, (37), anti-, at, :, (Abcam have published the article: The Amyloid Precursor Protein Copper Binding Domain Histidine Residues 149 and 151 Mediate APP Stability and Metabolism*, in the Journal: (JOURNAL) of February/22,/2012

SUMMARY

    During trafficking through the secretory pathway, APP undergoes various post-translational modifications, such as N- and O-glycosylation, phosphorylation, and tyrosine sulfation. The N-glycosylated only, immature APP is mainly found in the endoplasmic_reticulum/cis-Golgi . . .

     

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