HIGHLIGHTS
- who: Salah-Eddine Lamhamedi-Cherradi from the The University have published the research: The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors report the most extensive series of DSRCT patients to have undergone protein and transcriptomic profiling.
- how: As AR activity can be influenced by integrins and transcriptional co-regulators3031 the authors evaluated these AR activators within the same cohort of 11 DSRCT tumors at the proteomic level using a western blotting analysis. Having shown that DHT stimulates DSRCT_cells . . .
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