HIGHLIGHTS
- who: Top from the IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, France University of Rome "Tor Vergata, " , Rome, Italy have published the article: The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces, in the Journal: (JOURNAL)
- what: The authors show that the E3 ubiquitin ligase ITCH/ AIP4 binds to HER3 and activates HER3 ubiquitination and degradation induced by 9F7-F11. The authors demonstrate that the expression of the deubiquitinase USP9X, which activates ITCH stability, is increased in 9F7-F11-treated pancreatic cancer cells.
- how: For detection of activated JNK and . . .
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