The antileukemic activity of decitabine upon pml/rara-negative aml blasts is supported by all-trans retinoic acid: in vitro and in vivo evidence for cooperation

HIGHLIGHTS

• who: Ruth Meier from the (UNIVERSITY) have published the research: The antileukemic activity of decitabine upon PML/RARA-negative AML blasts is supported by all-trans retinoic acid: in vitro and in vivo evidence for cooperation, in the Journal: (JOURNAL) of 10/02/2022
• what: The authors demonstrate at least additive activity of DAC and ATRA on the cellular and transcriptional level, with increased chromatin accessibility, and massive reactivation of TEs, particularly in TP53-mutated U937 cells. The authors demonstrate cooperativity between both drugs in two AML cell lines, one-U937-with mutated TP53, the . . .
  

   

  

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