The ap-1 transcription factor fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions

HIGHLIGHTS

• who: Mara Stellato from the University Hospital Zurich, Zurich, Switzerland have published the paper: The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions, in the Journal: (JOURNAL) of 19/05/2022
• what: The authors aimed to characterize conduction abnormalities and arrhythmia susceptibility in Fosl-2tg mice and to elucidate the role of Fosl-2 and adaptive immune response in this cardiac pathology.
• how: The data showed that these cells co-expressed myofibroblast markers (u03b1SMA ADAM12 periostin) exerted contraction properties and secreted collagens which altogether clearly indicated a . . .
  

   

  

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