The autism-associated meis2 gene is necessary for cardiac baroreflex regulation in mice

HIGHLIGHTS

  • who: J. Roussel from the CNRS have published the research work: The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice, in the Journal: Scientific Reports Scientific Reports of 22/09/2010
  • what: Because in the above telemetric experiments no differences were evidenced between control WT and u00adIsl1+/CRE mice, the authors focused the analysis by comparing WT and Iu00ad sl1+/CRE::Meis2LoxP/LoxP mice only. The authors showed that specific inactivation of Meis2 TF in Isl1-expressing cells in mice severely impaired inhibitory baroreflex function independently of any developmental cardiac malformations . . .

     

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