The background of mitochondrial dna haplogroup j increases the sensitivity of leber’s hereditary optic neuropathy cells to 2,5-hexanedione toxicity

HIGHLIGHTS

• who: from the Dipartimento di Genetica e Microbiologia, Università di Pavia, Pavia, ItalyEditor: Paul Cobine, Auburn University, United States of America have published the Article: The Background of Mitochondrial DNA Haplogroup J Increases the Sensitivity of Leber’s Hereditary Optic Neuropathy Cells to 2,5-Hexanedione Toxicity, in the Journal: (JOURNAL) of November/19,/2009
• what: This study shows that mtDNA haplogroups modulate the response of LHON cells to 2 5-HD. The authors have investigated the toxic effect of 2,5HD in cybrids and fibroblasts bearing LHON mutations and evaluated the involvement of complex . . .
  

   

  

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