The binary toxin of clostridioides difficile alters the proteome and phosphoproteome of hep-2 cells

HIGHLIGHTS

  • who: Andreas Pich from the Institute of Toxicology, Hannover Medical School, Hanover, Germany, Core Facility Proteomics, Hannover Medical School, Ulm University Medical Center have published the article: The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells, in the Journal: (JOURNAL)
  • what: This study investigated the fundamental mechanism in the cell response to CDT treatment of human epithelial_cells (HEp2) by LC-MS-based proteomics utilizing a tandem mass tags (TMT)-based phosphoproteomic approach.

SUMMARY

    Mutant TcdA with impaired glucosyltransferase activity showed no effect on the proteome . . .

     

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