The c-terminal nuclear localization signal of the sex-determining region y (sry) high mobility group domain mediates nuclear import through importin β1*

HIGHLIGHTS

• who: Jade K. Forwood from the (UNIVERSITY) have published the article: The C-terminal Nuclear Localization Signal of the Sex-determining Region Y (SRY) High Mobility Group Domain Mediates Nuclear Import through Importin β1*, in the Journal: (JOURNAL) of February/22,/2001
• what: Using a range of quantitative binding assays including enzymelinked immunosorbent assay, fluorescence polarization, and native gel mobility electrophoresis, the authors assess the binding of importins to SRY, demonstrating a high affinity recognition (in the low nM range) by Imp␤ independent of Imp␣. The authors characterize the nuclear import properties of SRY for . . .
  

   

  

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