The c30-modulation of betulinic acid using 1,2,4-triazole: a promising strategy for increasing its antimelanoma cytotoxic potential

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    BA-TZ cytotoxic activity on HaCaT and RPMI-7951 cell lines was analysed using the BA-TZ cytotoxic activity on HaCaT and RPMI-7951 cell lines was analysed using MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) after a 24 h the MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) after a treatment period with various concentrations (0.08, 0.4, 2, 10 and 50 μM). At the highest concentration (50 all tested (BA, TZ and BA-TZ) TZ) significantly decreased cell viability vs.µM), control . . .

     

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