The calcium-binding protein s100b down-regulates p53 and apoptosis in malignant melanoma*

HIGHLIGHTS

• who: Jing Lin from the EXPERIMENTAL PROCEDURES Cells and Cell Treatments-The human malignant melanoma C A cell line was obtained from DrFrank L. Meyskens (University of California, Irvine, CA) (35-38), and the LOX-IM VI (LOX-MM), UACC-62, and , cells were purchased from the Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, MD). With the LOX-MM as an exception, which has low levels of S B and wild-type p53, the other melanoma cells all have elevated levels of S B and wild type of p, (26, ). Malignant melanoma cells . . .
  

   

  

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