The camp-epac-rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the ù±3ù²1 integrin but not the ù±6ù²4 integrin*

HIGHLIGHTS

• who: Jorrit M. Enserink from the which may affect cell adhesionInterestingly, in hematopoietic cells Rap, has been shown to bind to RAPL, which in turn would bind directly to and activate , integrins (54). However, it is unlikely that this protein also functions in Rap1induced cell adhesion in fibroblastic and epidermal cells, because its expression pattern is almost exclusively restricted to hematopoietic cells and spleen (54). Furthermore, Rap, has been shown to interact with the, ., domain of the cytoskeleton-associated protein Krit, (55). Many integrin-regulating proteins contain such a, ., domain, including talin and FAK. Rap, may directly . . .
  

   

  

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