HIGHLIGHTS
- who: Eleonora Panfili from the University of Verona, Italy have published the article: The catalytic inhibitor epacadostat can affect the non-enzymatic function of IDO1, in the Journal: (JOURNAL)
- what: This approach has been applied into an increasing number of solid malignancies and has significantly improved clinical outcomes in some of them . This study aims to investigate the effect of epacadostat on the IDO1 signalingmediated function. For the first time, this study shows that epacadostat, a small_molecule developed as catalytic inhibitor of IDO1, may also promote the signaling function of IDO1 and induce an immune . . .
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