HIGHLIGHTS
- who: Li Na Zhao and Philipp Kaldis from the Department of Clinical Sciences, Lund University, Malmou0308, Sweden, Lund University Diabetes Centre have published the article: The catalytic mechanism of the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2), in the Journal: (JOURNAL) of May/25,/2022
- what: Using computational modeling and simulations the authors propose that two magnesium ions are present at the active site whereby (i) Arg233 Asp225 and two water mole2- cules coordinate Mg2- A while MgA together with Arg233 stabilize the inorganic phosphate (Pi); (ii) Asp168 and three water molecules coordinate Mg2- B and MgB . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.