HIGHLIGHTS
SUMMARY
Obesity has become a pandemic in modern societies, and its treatment is a complex public health concern, being the fifth leading cause of death worldwide. Approximately ~ 28 million people around the world die as a result of overweight or obesity co-morbidities, including hypertension, dyslipidemia, insulin resistance, stroke, diabetes_mellitus, fatty liver disease, coronary heart diseases, cancer, and metabolic diseases. The aberrant behavior of basal autophagy contributes to the pathogenesis of several diseases, including cancer, cardiovascular diseases, obesity, diabetes_mellitus, and aging. The CB1 is widely expressed in central and peripheral tissues, including the central nervous . . .
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