The cdc42 target ack2 interacts with sorting nexin 9 (sh3px1) to regulate epidermal growth factor receptor degradation*

HIGHLIGHTS

• who: Qiong Lin from the (UNIVERSITY) have published the Article: The Cdc42 Target ACK2 Interacts with Sorting Nexin 9 (SH3PX1) to Regulate Epidermal Growth Factor Receptor Degradation*, in the Journal: (JOURNAL) of October/26,/2001
• what: The authors report the identification of another binding partner for ACK2 that has previously been implicated in endocytosis, namely the sorting nexin protein SH3PX1 (sorting nexin 9). The authors show that ACK2 and SH3PX1 work together to promote the degradation of the EGF receptor.

SUMMARY

Epidermal growth factor (EGF) stimulated the tyrosine phosphorylation of SH3PX1 . . .

 



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