The cell cycle regulator p16 promotes tumor infiltrated cd8+ t cell exhaustion and apoptosis

HIGHLIGHTS

  • What: Subsequently, Western blot analysis was conducted to assess the levels of antiapoptotic protein BCL-XL , and pro-apoptotic BAX . The authors demonstrated that the expression of the cell cycle regulator p16 in CD8+ T_cells was rapidly increased following TCR stimulation.
  • Who: Xin Zhang from the (UNIVERSITY) have published the paper: The cell cycle regulator p16 promotes tumor infiltrated CD8+ T cell exhaustion and apoptosis, in the Journal: (JOURNAL)
  • How: These results indicated that p16 and p19 may be involved in the exhaustion differentiation of CD8+ T_cells. All of the experiments were conducted . . .

     

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