The cell-permeable derivative of the immunoregulatory metabolite itaconate, 4-octyl itaconate, is anti-fibrotic in systemic sclerosis

HIGHLIGHTS

• who: John Henderson et al. from the NorthuMbria University, Ellison Place, Newcastle Upon Tyne , XA, UK have published the research work: The Cell-Permeable Derivative of the Immunoregulatory Metabolite Itaconate, 4-Octyl Itaconate, Is Anti-Fibrotic in Systemic Sclerosis, in the Journal: Cells 2021, 10, 2053. of 16/06/2021
• what: This work examines the role of the cell-permeable derivative of_(4-OI) in SSc. The authors show here that itaconate acts in both an anti-inflammatory and anti-fibrotic manner in dermal fibroblasts and that this is associated with upregulation of Nrf2-target . . .
  

   

  

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