The central inflammasome adaptor protein asc activates the inflammasome after transition from a soluble to an insoluble state

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  • who: Evan R. Prather from the Evan RPrather, Mikhail A. Gavrilin*, and Mark D. Wewers* From the Division of Pulmonary Critical Care and Sleep Medicine, Davis Heart and Lung Research Institute, Ohio State University Wexner Medical Center, Columbus, Ohio, USA Edited by Dennis Voelker have published the article: The central inflammasome adaptor protein ASC activates the inflammasome after transition from a soluble to an insoluble state, in the Journal: (JOURNAL)
  • what: The authors show that purified recombinant ASC spontaneously precipitated and was functional, whereas the maltose-binding protein-ASC fusion to ASC (promoting enhanced solubility . . .

     

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