The cgmp-dependent protein kinase ii is an inhibitory modulator of the hyperpolarization-activated hcn2 channel

HIGHLIGHTS

• who: Verena Hammelmann and collaborators from the Germany, Forschergruppe , Carvas, Technische Universitau0308t Muu0308nchen, Muu0308nchen, Germany GermanyEditor: Steven Barnes, Dalhousie University, Canada have published the article: The cGMP-Dependent Protein Kinase II Is an Inhibitory Modulator of the Hyperpolarization-Activated HCN2 Channel, in the Journal: (JOURNAL) of February/14,/2011
• what: The authors show for the first time that in the HCN2 channel cGMP can also exert an inhibitory effect on gating via cGMP-dependent protein kinase II (cGKII)-mediated phosphorylation. Using coimmunoprecipitation and immunohistochemistry the authors demonstrate that cGKII and HCN2 interact and colocalize with . . .
  

   

  

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