HIGHLIGHTS
- who: Chien-Chi Lu and colleagues from the Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan have published the Article: The Chemokine CCL4 Stimulates Angiopoietin-2 Expression and Angiogenesis via the MEK/ERK/STAT3 Pathway in Oral Squamous Cell Carcinoma, in the Journal: Biomedicines 2022, 10, 1612. of /2022/
- what: The authors demonstrate that CCL4 promotes Angpt2 expression in OSCC by activating signal transducer and activator of transcription 3 (STAT3) and mitogen-activated protein kinase kinase (MEK), signal-regulated kinase 1/2 (ERK) signaling, which subsequently enhances Angpt2-induced tumor angiogenesis. The study was . . .
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