The clc-k2 chloride channel is critical for salt handling in the distal nephron

HIGHLIGHTS

  • who: J. Christopher Hennings et al. from the University Hospital de Physiologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France have published the paper: The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron, in the Journal: (JOURNAL)
  • what: The authors show that disruption of Clcnk2 in the mouse leads to severe BS without hypercalciuria but with elevated levels of PGE2 in the urine. The less severe phenotype in patients may be explained by Here, the authors report the generation and characterization of a mouse . . .

     

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