HIGHLIGHTS
- who: Edward Courchaine from the (UNIVERSITY) have published the research work: The coilin N-terminus mediates multivalent interactions between coilin and Nopp140 to form and maintain Cajal bodies, in the Journal: (JOURNAL) of 24/07/2021
- what: The authors provide evidence that Nopp140 has condensation capacity and is required for CB assembly. From these observations, the authors propose a model in which coilin NTD-NTD mediated assemblies make multivalent contacts with Nopp140 to achieve biomolecular condensation in the nucleus. Specifically, the authors provide evidence that the coilin NTD contains at least two distinct faces on . . .
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