HIGHLIGHTS
SUMMARY
Following his discovery of thyroid parafollicular cells, these characteristics prompted A.G.E. Pearse to develop the APUD (Amine Precursor Uptake and Decarboxylation) cell theory and coin the term APUDoma for tumors of APUD cells throughout the body. Depending on their embryological origin, these cells may be divided into non-epithelial neuroendocrine cells or epithelial neuroendocrine cells (derived from the neuroectoderm). Due to the heterogeneity of these neoplasms, several different terms have been used to define example, epithelial neoplasms include described Duethem. to theFor heterogeneity of theseneuroendocrine neoplasms, several different terms tumors have been . . .
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