The crystal structure of ac-achbp in complex with α-conotoxin lvia reveals the mechanism of its selectivity towards different nachr subtypes

HIGHLIGHTS

• who: Manyu Xu from the for Structural Biology, Collaborative Innovation Center for Biotherapy, Tsinghua University, Beijing, China have published the research: The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes, in the Journal: (JOURNAL)
• what: The authors report the co-crystal structure of LvIA in complex with Aplysia californica acetylcholine binding protein (Ac-AChBP) at a resolution of 3.4 Å.
• how: Most interactions on the principal side were between the peptide and the C-loop (Gln-184~Tyr- To validate the . . .
  

   

  

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