The crystal structure of cytochrome p450 4b1 (cyp4b1) monooxygenase complexed with octane discloses several structural adaptations for ϋ-hydroxylation*⒦

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  • who: Mei-Hui Hsu from the Medicinal Chemistry, University of Washington, Seattle, Washington , have published the research: The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ϋ-Hydroxylation*⒦, in the Journal: (JOURNAL) of MARCH/31,/2017
  • what: The authors report successful crystallization of the N-terminally truncated enzyme in the presence of octane and determination of its structure to a 2.7-Å limiting resolution. For the final refinement of the model, a semi-empirical quantum mechanical approach was employed to minimize the Glu310/heme ester geometry in conjunction . . .

     

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