HIGHLIGHTS
SUMMARY
Atypical pain sensations, like allodynia (extreme sensitivity to usual non-painful tactile stimulation causing intensive pain), paradoxical heat sensation (gentle cooling perceived as hot or burning), and hypoesthesia (decreased pain sensitivity) are also reported for ASD. The authors will conclude by proposing an integrative view of the pain cycle, which, along with existing mechanisms of pain alterations in ASD, defines key targets for further pain research in ASD. To summarize the findings regarding the central brain responses and altered pain reactivity in ASD (see section July 2022 | Volume 13 | Article 910824 Paradox of Pain . . .
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