The determination of the effect(s) of solute carrier family 22-member 2 (slc22a2) haplotype variants on drug binding via molecular dynamic simulation systems

HIGHLIGHTS

• who: Zainonesa Abrahams-October from the Faculty University of have published the paper: The determination of the effect(s) of solute carrier family 22-member 2 (SLC22A2) haplotype variants on drug binding via molecular dynamic simulation systems, in the Journal: Scientific Reports Scientific Reports
• what: The study showed that Glibenclamide, Gliclazide, Dolutegravir, Isavuconazole, Vandetanib as well as Ranolazine to have stronger affinity for the SLC22A2 transporter than Metformin and the other six compounds . In this study, the structural and functional effects of mutation(s) present within haplotypes were evaluated within the SLC22A2 protein.
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