The development of cell-penetrating peptides for efficient and selective in vivo expression of mrna in spleen tissue

HIGHLIGHTS

• who: Ly Porosk and collaborators from the Institute of Technology, University of, Nooruse, have published the paper: The Development of Cell-Penetrating Peptides for Efficient and Selective In Vivo Expression of mRNA in Spleen Tissue, in the Journal: Pharmaceutics 2023, 15, 952. of 22/09/2021
• what: The authors characterize new cell-penetrating peptides NF424 and NF436 that exhibit preferential delivery of mRNA into the spleen after a single i.v. injection without the use of any active targeting mechanisms. The authors show that between the spleen liver and the lungs >95% of mRNA expression . . .
  

   

  

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